| 生物活性： |
靶点：AKT
通路：PI3K/Akt/mTOR
背景说明：据报道,能诱导成神经细胞瘤凋亡。
生物活性：Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity[1].
IC50：7.92μM(OVCAR-8 cell)[1]
In Vitro：Isobavachalcone(6.0-48.0 μM; 72 hours; OVCAR-8，PC3，A549，MCF-7，L-02 and HUVEC cells)treatment inhibits the proliferation of human cancer cells. Isobavachalcone inhibits PC3，A549，MCF-7，L-02 and HUVEC cells growth with IC50 values of 15.06 μM，32.2 μM，28.29 μM，31.61 μM and 31.3 μM，respectively.Isobavachalcone(0-18 μM; 6 hours; OVCAR-8 and PC3 cells)treatment results in a concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt and GSK3b phosphorylation.Isobavachalcone(0-18 μM; 72 hours; OVCAR-8 and PC3 cells)treatment causes apoptosis via caspase- and ROS-involved mitochondrial pathway[1].
In Vivo：Isobavachalcone(20 mg/kg; intraperitoneal injection; for 0.5-24 hours; female Kunming mice)treatment results in an increase in blood glucose levels，reaching a maximum within 1 hour and maintaining until 4 hours post-dosing[1].
数据来源文献：[1]. Jing H， et al. Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells. Cancer Lett. 2010 Aug 28;294(2):167-77.
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| 其它标识： |
MDL：MFCD00902090
SMILES：O=C(/C=C/C1=CC=C(C=C1)O)C2=CC=C(C(C/C=C(C)\C)=C2O)O
InChIKey：DUWPGRAKHMEPCM-IZZDOVSWSA-N
InChI：InChI=1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+
PubChem CID：5281255
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| 基本信息： |
CAS：20784-50-3
中文名称：补骨脂乙素
英文名称：Isobavachalcone
别名：4-Hydroxyisocordoim;异补骨脂查尔酮
分子式：C20H20O4
分子量：324.38
规格：10mg ; 10mM*1mL in DMSO ; 5mg
溶解性：Soluble in DMSO
纯度：HPLC≥98%
外观(性状)：Light yellow to yellow Solid
储存条件：Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
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| 靶点： |
AKT |
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