| 生物活性： |
靶点：HDAC;ER Stress inhibitor
通路：DNA Damage/DNA Repair;Epigenetics;NF-κB;ER Stress
背景说明：4-Phenylbutyric Acid是一种组蛋白去乙酰化酶 (HDAC) 和内质网应激 (ER) 抑制剂。
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| 其它标识： |
EC：EINECS 217-341-8
MDL：MFCD00004403
SMILES：C1=CC=C(C=C1)CCCC(=O)O
InChIKey：OBKXEAXTFZPCHS-UHFFFAOYSA-N
InChI：InChI=1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3，5-6H，4，7-8H2，(H，11，12)
PubChem CID：4775
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| 基本信息： |
CAS：1821-12-1
中文名称：4-苯基丁酸
英文名称：4-Phenylbutyric Acid
别名：4-苯基丁酸;Octyloniumbromide;SP63;苯丁酸;4-苯丁酸;苯基丁酸;4-Phenylbutanoicacid;4-PBA
分子式：C10H12O2
分子量：164.2
规格：100mg
溶解性：Soluble in DMSO ≥200mg/mL
纯度：≥98%
外观(性状)：White to off-white Solid
储存条件：Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
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| 靶点： |
HDAC;ER Stress inhibitor |
产品详情
使用本产品的案例（仅供参考）
In Vitro
Cell（human hepatoma cell line (HepG2)；0~5mM 4-PBA；4d）
To explore whether RD-induced apoptosis was mediated by ER stress, we constructed a cell model of the inhibition of ER stress. 4-phenyl butyric acid (4-PBA), an ER stress inhibitor, was purchased from Solarbio. It was added into the Rf medium at dosages of 0, 0.5, 2.5, and 5 mM. The cells were cultured in the above medium for 4 d for the ER stress-suppression assay and were subjected to subsequent apoptosis analyses.
来源文献：Zhang B, Cao JT, Wu YB, Gao KX, Xie M, Zhou ZK, Tang J, Hou SS. Riboflavin (Vitamin B2) Deficiency Induces Apoptosis Mediated by Endoplasmic Reticulum Stress and the CHOP Pathway in HepG2 Cells. Nutrients. 2022 Aug 16;14(16):3356. doi: 10.3390/nu14163356. PMID: 36014863; PMCID: PMC9414855.
In Vivo
Rats ( Sprague-Dawley (SD) rats; 5 mg/kg body weight 4-PBA, 饮水给药; 28 days)
Twenty SD rats were randomly divided into 4 groups(n = 5 per group): the control group (no periodontitis,G1), the experimental periodontitis group (ligature +LPS, G2), the LIPUS treatment group (ligature + LPS +LIPUS, G3), and the 4-PBA treatment group (ligature +LPS + 4-PBA, G4). General anesthesia was injected intraperitoneally with 10% chloral hydrate (5 mL/kg), and surgery was performed by two investigators. The gingiva of the maxillary first molar was separated with a dental probe, and then the 0.020 stainless steel ligature was inserted into the distal side and ring the maxillary first molar, and the ligature needs to be tied tightly. 0.1 ml LPS (10μg/ml) was injected at 48-h intervals, 4 times in total. After induction of periodontitis, G3 received treatment of LIPUS (90 mW/cm2, 1.5 mHz,30 min) for 28 days, and G4 was fed with 4-PBA solution at a final concentration of 5 mg/kg body weight through drinking water for 28 days. Eight weeks after the induction of periodontitis, the rats (n = 5 per group) were euthanized and samples were obtained for further experimental analyses.
来源文献：Li H, Deng Y, Tan M, Feng G, Kuang Y, Li J, Song J. Low-intensity pulsed ultrasound upregulates osteogenesis under inflammatory conditions in periodontal ligament stem cells through unfolded protein response. Stem Cell Res Ther. 2020 Jun 3;11(1):215. doi: 10.1186/s13287-020-01732-5. PMID: 32493507.
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