| 生物活性： |
靶点：HIV(Vpr)
通路：Anti-infection
背景说明：Bellidifolin 能作为病毒蛋白 R (Vpr) 的抑制剂。
生物活性：Bellidifolin 是一种从獐牙菜中分离出来的黄酮，具有保肝、降血糖、抗氧化、抗炎和抗肿瘤活性，还是一种病毒蛋白 R（Vpr）抑制剂。[1-4]
In Vitro：Bellidifolin(20 or 40 μmol/L)prior to hypoxia significantly increased the survival rate of pheochromocytoma cells.[1] Bellidifolin exhibited notable hepatoprotective activities against carbon tetrachloride(CCl4)-induced HepG2 cell damage.[2] Bellidifolin was potent Vpr inhibitors with an effective dose of 10 μM.[4]
In Vivo：Bellidifolin showed a potent and dose-dependent hypoglycemic activity in STZ-induced diabetic rats both in i.p. and p.o. administration.[3]
数据来源文献：[1]. Zhao ZY，et al. Protective effects of bellidifolin in hypoxia-induced in pheochromocytoma cells (PC12) and underlying mechanisms. J Toxicol Environ Health A. 2017;80(22):1187-1192.
[2]. Zheng XY，et al. Two xanthones from Swertia punicea with hepatoprotective activities in vitro and in vivo. J Ethnopharmacol. 2014 May 14;153(3):854-63.
[3]. Basnet P，et al. Bellidifolin: a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Planta Med. 1994 Dec;60(6):507-11.
[4]. Woo SY，et al. Viral protein R inhibitors from Swertia chirata of Myanmar. J Biosci Bioeng. 2019 Oct;128(4):445-449.
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| 其它标识： |
MDL：MFCD00808528
SMILES：COC1=CC(=C2C(=C1)OC3=C(C=CC(=C3C2=O)O)O)O
InChIKey：JDIORNFCMMYMLF-UHFFFAOYSA-N
InChI：InChI=1S/C14H10O6/c1-19-6-4-9(17)11-10(5-6)20-14-8(16)3-2-7(15)12(14)13(11)18/h2-5，15-17H，1H3
PubChem CID：5281623
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| 基本信息： |
CAS：2798-25-6
中文名称：龙胆山酮酚
英文名称：Bellidifolin
别名：龙胆山酮酚;Prophenpyridaminemaleate;Tripotonmaleate;
分子式：C14H10O6
分子量：274.23
规格：1mg
溶解性：Soluble in DMSO
纯度：HPLC≥98%
外观(性状)：Light yellow to yellow Solid
储存条件：Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
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| 靶点： |
HIV(Vpr) |
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