| 生物活性： |
靶点：HIV
通路：Anti-infection
背景说明：是HIV-1蛋白酶高活性抑制剂。
生物活性：BMS-232632 is an azapeptide human immunodeficiency virus type 1 (HIV-1) protease (Prt) inhibitor that exhibits potent anti-HIV activity with a 50% effective concentration (EC(50)) of 2.6 to 5.3 nM and an EC(90) of 9 to 15 nM in cell culture. [1]
In Vitro：BMS-232632 blocks the cleavage of viral precursor proteins in HIV-infected cells，proving that it functions as an HIV Prt inhibitor. Comparative studies showed that BMS-232632 is generally more potent than the five currently approved HIV-1 Prt inhibitors. Furthermore，BMS-232632 is highly selective for HIV-1 Prt and exhibits cytotoxicity only at concentrations 6，500- to 23，000-fold higher than that required for anti-HIV activity. [1]
数据来源文献：[1] Robinson BS， et al. Antimicrob Agents Chemother， 2000， 44(8)， 2093-2099.
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| 其它标识： |
EC：EINECS 620-495-2
MDL：MFCD08067748
SMILES：O=C(OC)N[C@@H](C(C)(C)C)C(NN(CC1=CC=C(C2=NC=CC=C2)C=C1)C[C@H](O)[C@H](CC3=CC=CC=C3)NC([C@H](C(C)(C)C)NC(OC)=O)=O)=O.O=S(O)(O)=O
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| 基本信息： |
CAS：229975-97-7
中文名称：硫酸阿扎那韦
英文名称：Atazanavir sulfate
别名：硫酸阿扎那韦;BMS-232632-05;阿扎那韦硫酸盐;
分子式：C38H52N6O7·H2SO4
分子量：802.93
规格：50mg ; 10mg ; 100mg
溶解性：Soluble in DMSO
纯度：HPLC≥99%
外观(性状)：White to yellow Solid
储存条件：Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
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| 靶点： |
HIV |
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