| 生物活性： |
靶点：BMP4
通路：TGF-beta/Smad
背景说明：BMP signaling agonist sb4 是一种有效的bone morphogenetic protein 4 (BMP4) 信号激动剂，通过稳定细胞内 p-SMAD-1/5/9 激活 BMP 信号。BMP signaling agonist sb4 还能激活典型 BMP 信号通路中的 BMP4 靶基因 。
生物活性：BMP signaling agonist sb4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM， activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9. BMP signaling agonist sb4 activates BMP4 target genes (inhibitors of DNA binding， Id1 and Id3) canonical BMP signaling[1].
In Vitro：BMP signaling agonist sb4(1 μM; 0-60 mins)enhances the efficacy of signaling at each concentration of rhBMP4 tested. This effect is most pronounced at low concentrations of rhBMP4，whereby sb4 increases BRE-luc expression 2-fold at 0.4 ng/ml of rhBMP4.BMP signaling agonist sb4(0.05 μM-1 μM; 24 hours)induces phosphorylated SMAD-1/5/9 in a dose-dependent manner in PRECs cells under serum-starved conitions[1].
数据来源文献：[1]. Bradford STJ， et al. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds.J Biol Chem. 2019 Mar 1;294(9):3125-3136.
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| 其它标识： |
MDL：MFCD01603921
SMILES：C1=CC=C2C(=C1)N=C(O2)SCC3=CC=C(C=C3)Br
InChIKey：JDVOIBFEFVKUPL-UHFFFAOYSA-N
InChI：InChI=1S/C14H10BrNOS/c15-11-7-5-10(6-8-11)9-18-14-16-12-3-1-2-4-13(12)17-14/h1-8H，9H2
PubChem CID：731364
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| 基本信息： |
CAS：100874-08-6
英文名称：BMP signaling agonist sb4
分子式：C14H10BrNOS
分子量：320.2
规格：5mg
溶解性：Soluble in DMSO ≥5mg/mL(Need ultrasonic)
纯度：≥98%
外观(性状)：Light yellow to light brown Solid
储存条件：Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
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| 靶点： |
BMP4 |
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