| 生物活性： |
靶点：Syk
通路：Protein Tyrosine Kinase/RTK
背景说明：Fostamatinib是Syk抑制剂。
生物活性：Fostamatinib (formerly also known as R788; trade name: Tavalisse), a prodrug of the active metabolite R406, is an orally bioactive, potent and selective Syk inhibitor with potential anti-inflammatory activity. It inhibits Syk with an IC50 of 41 nM in a cell-free assay. On April 17th 2018, Fostamatinib was approved by the US FDA for the treatment of thrombocytopenia in adult patients with persistent or chronic immune thrombocytopenia (ITP).[1]
数据来源文献：[1]. Blood. 2010 Dec 2;116(23):4894-905; Blood. 2008 Feb 15;111(4):2230-7.
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