| 抗体信息： |
靶标：TFRC
别名：TFRC,CD71,IMD46,T9,TFR,TFR1,TR,TRFR,p90
背景说明：Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738).Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738).
Swiss Prot：P02786
Gene ID：7037
亚细胞定位：Cell membrane Secreted
免疫原：Recombinant protein of human TFRC
Public Immunogen Range：101-450aa
理论分子量：85kDa
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