靶点：NF-kB 通路：NF-κB 背景说明：1-Caffeoylquinic acid是一种有效的NF-κB抑制剂,对p105的RH结构域显示出显著的结合亲和力。具有抗氧化应激能力。抑制PD-1/PD-L1相互作用。 生物活性：1-Caffeoylquinic acid is an effective NF-κB inhibitor， shows significant binding affinity to the RH domain of p105 with Ki of 0.002 μM and binding energy of 1.50 Kcal/mol[1]. 1-Caffeoylquinic acid has anti-oxidative stress ability[2]. 1-Caffeoylquinic acid inhibits PD-1/PD-L1 interact[3]. 数据来源文献：[1]. Khan MK， et al. Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105. Pharmacogn Mag. 2013 Jan;9(33):51-7. [2]. Jiang Y， et al. Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model. BMC Complement Altern Med. 2017 Jun 17;17(1):320. [3]. Han Y， et al. PD-1/PD-L1 inhibitor screening of caffeoylquinic acid compounds using surface plasmon resonance spectroscopy. Anal Biochem. 2018 Apr 15;547:52-56.
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