| 生物活性： |
靶点：Nrf2
通路：NF-κB
背景说明：是一种Nrf2的活化剂。
生物活性：3-acetyl-11-keto-β-Boswellic Acid， as known as AKBA， is a pentacyclic triterpene that suppresses 5-lipoxygenase in a selective， nonredox， enzyme-directed， and noncompetitive manner. Also， AKBA inhibits topoisomeraseⅠ and NF-κB signaling. AKBA has been studied for potential use in the control of inflammatory diseases， including arthritis and cancer.[1]
In Vitro：AKBA exerted a time- and concentration -dependent cytotoxicity on androgen-independent prostate cancer cells. AKBA blocked proliferation and elicited apoptosis in the chemoresistant and androgen-independent human PC-3 prostate cancer cells by the release of mitochondrial cytochrome c and DNA fragmentation. Also，AKBA concentration-dependently inhibited NF-κB signaling，yet it did not directly affect the NF-κB binding to DNA. Additionally，AKBA suppressed inhibitor κB kinase and NF-κB-dependent antiapoptotic gene products in PC-3 cells [1].
In Vivo：PC-3 xenotransplanted male NMRI/nu-nu mice were injected intraperitoneally at 100 μmol/kg daily for three weeks. AKBA dampened growth and proliferation of PC-3 xenografts in nude mice and elicited apoptosis. Moreover，compared with the control group，AKBA reduced the tumor volume and the invasiveness of the tumor into the surrounding tissues [1].
数据来源文献：[1]. Syrovets， T.， Gschwend， J.， Buchele， B.， Laumonnier， Y.， Zugmaier， W.， Genze， F.， & Simmet， T. Inhibition of IκB Kinase Activity by Acetyl-boswellic Acids Promotes Apoptosis in Androgen-independent PC-3 Prostate Cancer Cells in Vitro and in Vivo. Journal of Biological Chemistry. 2004; 280(7): 6170-6180.
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| 其它标识： |
MDL：MFCD03788777
SMILES：C[C@@]([C@@](C1=C2)(CC[C@@](C)(CC[C@H]3C)[C@@]1([H])[C@H]3C)C)(CC[C@@]4([H])[C@@]5(C)C(O)=O)[C@@](C2=O)([H])[C@]4(CC[C@H]5OC(C)=O)C
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| 基本信息： |
CAS：67416-61-9
中文名称：3-乙酰基-11-酮基-β-乳香酸
英文名称：3-O-Acetyl-11-keto-β-boswellic Acid
别名：乙酰基-11-酮基-beta-乳香酸;Acetyl-11-keto-β-boswellic acid;AKBA
分子式：C32H48O5
分子量：512.72
规格：5mg ; 10mg
溶解性：Soluble in DMSO ≥1mg/mL(Need ultrasonic)
纯度：≥98%
外观(性状)：White to yellow Solid
储存条件：Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
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| 靶点： |
Nrf2 |
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