| 生物活性： |
背景说明：PEN (human) 是由 ProSAAS 原蛋白衍生而来的最丰富的下丘脑神经肽之一，是 GPR83 的内源性配体。
In Vitro：Mouse PEN (mPEN) and rat PEN (rPEN) only differ by one residue at the N-terminal end， whereas human PEN (hPEN) is more divergent and has the sequence PEG instead of PEN.
PEN binds and activates a GPCR in the brain.
参考文献：[1]. Seshat M Mack， et al. Neuropeptide PEN and Its Receptor GPR83: Distribution， Signaling， and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891.
[2]. Ivone Gomes， et al. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9(425):ra43.
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