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背景说明:Nocistatin (human) 可抑制痛觉刺激引起的痛觉过敏和痛觉异常,缓解前列腺素prostaglandin E2 引起的疼痛。 In Vitro:Nocistatin (5.0 nmol) significantly improves the nociception (5.0 nmol)-induced impairment of learning and memory without changing motor activity or response to electric shocks. 参考文献:[1]. E Okuda-Ashitaka, et al. Nocistatin, a peptide that blocks nociceptin action in pain transmission. Nature. 1998 Mar 19;392(6673):286-9. [2]. M Hiramatsu, et al. Effects of nocistatin on nociceptin-induced impairment of learning and memory in mice. Eur J Pharmacol. 1999 Feb 19;367(2-3):151-5.
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