背景说明：Small Cardioactive Peptide B (SCPB) 是一种神经活性肽，刺激心脏和鳃组织的颗粒组分中的腺苷酸环化酶 (adenylate cyclase) 活性，EC50 分别为 0.1 和 1.0 μM。 In Vitro：Small cardioactive peptide B (SCPB) is a neurally active peptide endogenous to Aplysia. Small cardioactive peptide B (SCPB) possesses cardioexcitatory effects in Aplysia and reported a threshold concentration of 0.01 nM for both native and synthetic Small cardioactive peptide B (SCPB) stimulated effects on the isolated heart. Effects of Small Cardioactive Peptide B (SCPB) on the physiology of the isolated heart and gill preparations from the mollusc Aplysia californica were examined. In addition， the effects of Small Cardioactive Peptide B (SCPB) and FMRFamide (Phe-Met-Arg-Phe-NH2) on adenylate cyclase activity are compared in particulate fractions of heart and gill tissues， respectively. Small Cardioactive Peptide B (SCPB) is found to exert dose-dependent， reversible changes in cardiac activity when perfused through the isolated heart. The EC50 values effecting changes in heart rate and force of contraction are 0.03 and 0.3 nM， respectively; minimum concentrations find to effect changes in heart rate and force of contraction are normally 0.001 and 1 pM， respectively. When perfused through the isolated gill， Small Cardioactive Peptide B (SCPB) is found to suppress the gill withdrawal response amplitude with a threshold concentration of 0.01 pM and an EC50 value of 0.03 nM. Suppression of the gill withdrawal response amplitude by Small Cardioactive Peptide B (SCPB)is found to be dose dependent and reversible up to a concentration of 1nM. At higher concentrations， the suppression tended to persist irreversibly. Small Cardioactive Peptide B (SCPB) stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with an EC50 of 0.1 and 1.0μM， respectively. 参考文献：[1]. Cawthorpe DR， et al. The effects of small cardioactive peptide B on the isolated heart and gill of Aplysia californica. Can J Physiol Pharmacol. 1985 Aug;63(8):918-24.
基本信息：
产品类型：多肽 CAS：84746-43-0 单字母序列：MNYLAFPRM-NH2 三字母序列：Met-Asn-Tyr-Leu-Ala-Phe-Pro-Arg-Met-NH2 分子式：C52H80N14O11S2 分子量：1141.41 纯度：≥95% 外观(性状)：冻干粉;Lyophilized powder 溶解性：H2O：50 mg/mL; *超声助溶; 盐体系：TFA盐;Trifluoroacetate salt 来源：合成;Synthetic 储存条件：Store at -20℃，2 years.(Avoid freeze/thaw cycles) 类别/标签：激素和相关肽（Hormone and Related Peptides） 规格：5mg ; 1mg
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