靶点：TNF Receptor 通路：Apoptosis 背景说明：据报道,桑皮苷A 具有抗酪氨酸酶活性。 生物活性：Mulberroside A is a natural polyhydroxylated stilbene compound present at relatively high abundance in the roots and twigs of Morus alba L. It is known for its nephroprotective， hypoglycemic， and antidiabetic effects.Mulberroside A is a candidate for the treatment of ischemic stroke， which would act as a multifactorial neuroprotectant.[2] In Vitro：The mechanistic studies showed that mulberroside A decreased the expressions of tumor necrosis factor-α(TNF-α)，interleukin(IL)-1β，and IL-6 and inhibited the activation of NALP3，caspase-1，and nuclear factor-κB and the phosphorylation of extracellular signal-regulated protein kinases，the c-Jun N-terminal kinase，and p38，exhibiting anti-inflammatory antiapoptotic effects. [2] In Vivo：Mulberroside A at 10，20，and 40 mg/kg decreased serum uric acid levels and increased urinary urate excretion and fractional excretion of uric acid in hyperuricemic mice. Simultaneously，it reduced serum levels of creatinine and urea nitrogen(10-40 mg/kg)，urinary N-acetyl- β-D-glucosaminidase activity(10-40 mg/kg)，β -microglobulin(10-40 mg/kg)and albumin(20-40 mg/kg)，and increased creatinine clearance(10-40 mg/kg)in hyperuricemic mice. Furthermore，mulberroside A downregulated mRNA and protein levels of renal glucose transporter 9(mGLUT9)and urate transporter 1(mURAT1)，and upregulated mRNA and protein levels of renal organic anion transporter 1(mOAT1)and organic cation and carnitine transporters(mOCT1，mOCT2，mOCTN1，and mOCTN2)in hyperuricemic mice.[1] 数据来源文献：[1]. Cai-Ping Wang，et al. Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice. Planta Med. 2011 May;77(8):786-94. [2]. Wang CP， et al. Mulberroside A protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion. J Neurosci Res. 2014 Jul;92(7):944-54.
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