| 生物活性： |
靶点：Serotonin Transporter
通路：Neuronal Signaling
背景说明：是一种选择性血清素再摄取抑制剂 (SSRI)，抑制 5-HT 摄取进入突触体。
生物活性：Citalopram Hydrobromide 是一种新的双环酞烷衍生物，是神经元血清素（5-HT）摄取的强效抑制剂，IC50 为 1.8 nM。可抑制兔血小板对 5-HT 的摄取，IC50 为 14 nM。抗抑郁作用。[1]
In Vitro：Citalopram and escitalopram showed concentration-dependent cytotoxicity on 2 non-MYCN amplified cell lines(rat B104 and human SH-SY5Y)and 2 human MYCN amplified cell lines(IMR32 and Kelly). Citalopram was more cytotoxic than escitalopram. IMR32 was the most sensitive cell line.[2]
In Vivo：In the Spontaneously Hypertensive rats(SHRs)，Lewis(LEW)rats，and Wistar-Kyoto(WKY)rats，citalopram(1-10 mg/kg，i.p.)pretreatment increased central 5-HT levels and/or decreased 5-hydroxyindoleacetic acid levels.[3]
动物实验：Acute administration of the selective serotonin(5-HT)reuptake inhibitor(SSRI)，citalopram(1-10 mg/kg，i.p. 1 h before an elevated plus-maze test)，to Spontaneously Hypertensive rats(SHRs)，Lewis(LEW)rats，and Wistar-Kyoto(WKY)rats，i.e.，rat strains differing for their emotionality，promoted anxiety，and/or hypoactivity，except in WKY rats.[3]
数据来源文献：[1]. Hyttel J. Citalopram--pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(3):277-95.
[2]. Sakka L，et al. Assessment of citalopram and escitalopram on neuroblastoma cell lines. Cell toxicity and gene modulation. Oncotarget. 2017 Jun 27;8(26):42789-42807.
[3]. Pollier F，et al. Serotonin reuptake inhibition by citalopram in rat strains differing for their emotionality. Neuropsychopharmacology. 2000 Jan;22(1):64-76.
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| 其它标识： |
EC：EINECS 261-890-6
MDL：MFCD02101306
SMILES：CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.Br
InChIKey：WIHMBLDNRMIGDW-UHFFFAOYSA-N
InChI：InChI=1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9，12H，3，10-11，14H2，1-2H3;1H
PubChem CID：77995
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| 基本信息： |
CAS：59729-32-7
中文名称：氢溴酸西肽普兰
英文名称：Citalopram Hydrobromide
别名：Prepram HBr;Bonitrile HBr;Citalopram HBr;Lu 10-171;XU-62-320;Nitalapram HBr;(±)-Citalopram hydrobromide
分子式：C20H22BrFN2O
分子量：405.3
规格：10mg ; 25mg
溶解性：Soluble in Water/DMSO(Need ultrasonic)
纯度：≥98%
外观(性状)：White to off-white Solid
储存条件：Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
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| 靶点： |
Serotonin Transporter |
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