| 生物活性： |
靶点：GABA Receptor
通路：Neuronal Signaling;GPCR & G Protein
背景说明：是一种GABAA拮抗剂。
生物活性：Bemegride 是一种中枢神经兴奋剂，也是巴比妥酸盐中毒的解毒剂。[1-2]
In Vitro：Bemegride had an antagonistic action on the GABAA receptor，suppressing both GABA- and pentobarbitone-evoked whole-cell currents.[1]
In Vivo：Long-term oral administration to the rat of barbitone，alone or together with the analeptics bemegride or pentylenetetrazol，has shown that the intensity of the withdrawal syndrome generally parallels the degree of associated CNS depression.[2]
数据来源文献：[1]. Mistry DK，et al. Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture. Exp Physiol. 1990 Mar;75(2):199-209.
[2]. Arblaster CI，et al. Studies on the development of physical dependence on barbitone in the rat and rat atrium. Farmaco Sci. 1986 Jan;41(1):3-22.
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| 其它标识： |
EC：EINECS 200-588-0
MDL：MFCD00006673
SMILES：CCC1(CC(=O)NC(=O)C1)C
InChIKey：ORRZGUBHBVWWOP-UHFFFAOYSA-N
InChI：InChI=1S/C8H13NO2/c1-3-8(2)4-6(10)9-7(11)5-8/h3-5H2，1-2H3，(H，9，10，11)
PubChem CID：2310
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| 基本信息： |
CAS：64-65-3
中文名称：贝美格
英文名称：Bemegride
别名：3-Ethyl-3-methylglutarimide;Agipnon
分子式：C8H13NO2
分子量：155.19
规格：50mg
溶解性：Soluble in DMSO(Need ultrasonic)
纯度：≥98%
外观(性状)：White to off-white Solid
储存条件：Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
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| 靶点： |
GABA Receptor |
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