| 生物活性： |
靶点：AChE
通路：Neuronal Signaling
背景说明：是一种乙酰胆碱酯酶抑制剂。
生物活性：Corydaline 是从延胡索堇菜中分离出来的一种异喹啉生物碱，是一种 AChE 抑制剂，其 IC50 值为 226 μM。也是一种μ-阿片受体激动剂，Ki值为1.23 μM。可抑制肠病毒71（EV71）的复制，IC50为25.23 μM。具有抗血管生成、抗过敏、抗痛觉等活性。[1-3]
In Vitro：Corydaline inhibited AChE activity in a dose-dependent manner，and the IC values was 0.74 ± 0.06.[1] Corydaline could suppress the expression of viral structural and non-structural proteins. Corydaline inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro.[2]
In Vivo：Corydaline(12.5-50 μM，24 h)as new MOR agonists that produce antinociceptive effects in mice after subcutaneous administration via a MOR-dependent mechanism.[3]
数据来源文献：[1]. Xiao HT，et al. Acetylcholinesterase inhibitors from Corydalis yanhusuo. Nat Prod Res. 2011 Sep;25(15):1418-22.
[2]. Wang HQ，et al. Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression. J Asian Nat Prod Res. 2017 Nov;19(11):1124-1133.
[3]. Kaserer T，et al. Identification and characterization of plant-derived alkaloids，corydine and corydaline，as novel mu opioid receptor agonists. Sci Rep. 2020 Aug 14;10(1):13804.
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| 其它标识： |
MDL：MFCD00065280
SMILES：CC1C2C3=CC(=C(C=C3CCN2CC4=C1C=CC(=C4OC)OC)OC)OC
InChIKey：VRSRXLJTYQVOHC-YEJXKQKISA-N
InChI：InChI=1S/C22H27NO4/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23/h6-7，10-11，13，21H，8-9，12H2，1-5H3/t13-，21+/m0/s1
PubChem CID：101301
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| 基本信息： |
CAS：518-69-4
中文名称：延胡索碱甲
英文名称：Corydaline
别名：延胡索甲素;Corydalin;(+)-Corydaline;紫堇碱
分子式：C22H27NO4
分子量：369.45
规格：1mg ; 2mg
溶解性：Soluble in DMSO ≥3mg/mL
纯度：≥98%
外观(性状)：White to off-white Solid
储存条件：Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
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| 靶点： |
AChE |
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