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背景说明：(Arg)9 (Nona-L-arginine) 是一种由 9 个精氨酸残基组成的细胞穿透肽 (CPP)。(Arg)9 具有神经保护功能，在谷氨酸模型中 IC50 值为 0.78 μM。
(Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 has neuroprotective property， exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
In Vivo：(Arg)9 (Nona-L-arginine; 1?μM/kg (600? μL); i.v.; once， for 30min; male Sprague–Dawley ratspermanent middle cerebral artery stroke model) shows neuroprotective effects and reduces infarct volume.
In Vitro：(Arg)9 (Nona-L-arginine; 5-10 μM) provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC50=0.78 μM). Following kainic acid exposure， (Arg)9 is neuroprotective， but less effective than in the glutamic acid model (IC50=0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC50=6 μM).
参考文献：[1]. Meloni BP， et， al. The neuroprotective efficacy of cell-penetrating peptides TAT， penetratin， Arg-9， and Pep-1 in glutamic acid， kainic acid， and in vitro ischemia injury models using primary cortical neuronal cultures. Cell Mol Neurobiol. 2014 Mar;34(2):173-81.
[2]. Meloni BP， et， al. Poly-arginine and arginine-rich peptides are neuroprotective in stroke models. J Cereb Blood Flow Metab. 2015 Jun;35(6):993-1004.
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