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背景说明：这是一个16个氨基酸的肽，对应于果蝇触角体DNA结合域内的区域，该区域被定位为负责细胞内化。这种肽也叫穿透素。这种肽在37℃和4℃都能通过质膜转移到活细胞的胞浆和细胞核。
In Vitro：Antennapedia (Antp)-SMCC-cytochrome c conjugate (5 μg/mL) activates caspase-dependent apoptosis of HeLa cells. The Antp-SMCC-cytochrome c conjugate reduces the clonogenic survival of Hela cells, and inhibits clonogenic survival.
ANTP-SmacN7 fusion protein can transduce and accumulate in cells, while SmacN7 alone cannot. ANTP-SmacN7 fusion proteins have a radiation-sensitising effect on EC109 cells. ANTP-SmacN7 combined with radiation does not promote further increases in caspase-3 protein expression, it increases the levels of cleaved caspase-3.
参考文献：[1] Pietersz GA. et al. Vaccine. 19:1397-1405 (2001);
[2] Christiaens B. et al. Eur J Biochem. 27(16):1187-1197 (2004).
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