| 生物活性： |
靶点：Fungal
通路：Anti-infection
背景说明：Tolnaftate是一种硫代氨基甲酸酯类抗真菌化合物。
生物活性：Tolnaftate 是一种硫代氨基甲酸酯类抗真菌化合物，对厌氧菌、原生动物和一系列病毒具有活性。[1-2]
In Vitro：The thiocarbamate antimycotics tolnaftate blocked sterol biosynthesis in fungal cells and cell extracts，with accumulation of squalene. In whole Candida cells，ergosterol biosynthesis inhibition was not complete at drug concentrations up to 100 mg/liter，whereas full inhibition occurred in a cell-free test system.[1] Tolnaftate inhibited sterol biosynthesis，with the concentrations that caused a 50% decrease in the total sterol-to-squalene ratio ranging from less than or equal to 0.01 microM for terbinafine and SDZ 87-469 to 500 microM for tolnaftate.[2]
数据来源文献：[1]. Ryder NS，et al. Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother. 1986 May;29(5):858-60.
[2]. Georgopapadakou NH，et al. Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother. 1992 Aug;36(8):1779-81.
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| 其它标识： |
EC：EINECS 219-266-6
MDL：MFCD00056611
SMILES：CC1=CC(=CC=C1)N(C)C(=S)OC2=CC3=CC=CC=C3C=C2
InChIKey：FUSNMLFNXJSCDI-UHFFFAOYSA-N
InChI：InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H，1-2H3
PubChem CID：5510
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| 基本信息： |
CAS：2398-96-1
中文名称：托萘酯
英文名称：Tolnaftate
别名：托萘酯;Tolnaftate;
分子式：C19H17NOS
分子量：307.41
规格：500mg
溶解性：Soluble in DMSO(Need ultrasonic)
纯度：≥98%
外观(性状)：White to off-white Solid
储存条件：Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
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| 靶点： |
Fungal |
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