| 生物活性： |
靶点：Bacterial
通路：Anti-infection
背景说明：是抗生素,有抗结核功效。
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| 其它标识： |
EC：EINECS 200-214-6
MDL：MFCD00006426
SMILES：O=C(C1=CC=NC=C1)NN
InChIKey：QRXWMOHMRWLFEY-UHFFFAOYSA-N
InChI：InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
PubChem CID：3767
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| 基本信息： |
CAS：54-85-3
中文名称：异烟肼
英文名称：Isoniazid
别名：Isonicotinic hydrazide;INH
分子式：C6H7N3O
分子量：137.14
规格：100mg ; 10mM*1mL in Water ; 250mg ; 500mg
溶解性：Soluble in Water ≥10mg/mL
纯度：HPLC≥98%
外观(性状)：White to off-white Solid
储存条件：Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
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| 靶点： |
Bacterial |
产品详情
是一种前体药物，通过与KatG 相互作用阻断了脂肪酸合成酶的作用，可用于结核的相关研究。
使用案例（仅供参考）
In Vivo
Mice（female mice；0~75 mg/kg Isoniazid, i.p）
On the conditioning phase of the CPP procedure, ten groups of the animals received morphine (0, 0.75, 1.5, 3, 5, and 10 mg/kg, s.c.) or isoniazid (0, 25, 50, and 75 mg/kg, i.p.) to induce CPP. Then, the effects of isoniazid on the acquisition and expression of morphine-induced CPP were evaluated.
In the expression experiment, four groups of mice were conditioned with an effective dose of morphine (5mg/kg, s.c.). Then, the animals received saline or isoniazid (25, 50, and 75 mg/kg) one hour before the test, intraperitoneally.
In the acquisition experiment, the other four groups received intraperitonealsaline or isoniazid (25, 50, and 75 mg/kg, i.p.) one hour before receiving the effective dose of morphine (5mg/kg, s.c.) on conditioning phase. On the test day, these animals received no treatment.
来源文献：A Barzegari, K Shahabi .The Effects of Isoniazid on the Acquisition and Expression of Morphine-Induced Conditioned Place Preference in Mice.JKMU.2020; 27 (1): 69-81
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