| 生物活性： |
靶点：Parasite
通路：Anti-infection
背景说明：是一类具有杀虫、杀螨、杀线虫活性的十六元大环内酯化合物。
生物活性：Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and autophagy[1-4].
In Vitro：Avermectin B1(0-80 μM，12 h)induces cytotoxicity through MAPK and ATM/ATR pathway in mouse embryonic fibroblast(MEF)cells，and induces ROS-mediated DNA damage[1].Avermectin B1(36 μg/mL，72 h)has strong nematicidal efect of on G. pallida in aqueous solution，and negatively influences viability and infectivity of G. pallida J2 detected in potato roots(cv. Spunta)[2].Abamectin(10 μM，24 h)induces significant cytotoxicity by overproduction of ROS in haemocytes of Erocheir sinensis[3].Abamectin(4 μM，24 h)induces apoptosis and autophagy by inhibiting ROS-mediated PI3K/AKT signaling in MGC803 cells[4].
数据来源文献：[1]. [1] Yiran Liang， et al. Abamectin induces cytotoxicity via the ROS， JNK， and ATM/ATR pathways. PLoS One. Environ Sci Pollut Res Int. 2020 Apr;27(12):13726-13734.
[2]. Nicola Sasanelli， et al. Abamectin Efficacy on the Potato Cyst Nematode Globodera pallida. Plants (Basel). 2019 Dec 19;9(1):12.
[3]. Yi Huang， et al. Cytotoxicity induced by abamectin exposure in haemocytes of Chinese mitten crab， Eriocheir sinensis. Environ Toxicol Pharmacol. 2020 Jul;77:103384.
[4]. Shanshan Zhu， et al. Abamectin induces apoptosis and autophagy by inhibiting reactive oxygen species-mediated PI3K/AKT signaling in MGC803 cells. J Biochem Mol Toxicol. 2019 Jul;33(7):e22336.
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| 其它标识： |
EC：EINECS 200-096-6
MDL：MFCD01769550
SMILES：C[C@@H](CC)[C@]1([H])[C@@H](C)C=C[C@@]2(O[C@@]3([H])C[C@]([H])(OC([C@@]4([H])[C@@](/C(CO5)=C/C=C/[C@H](C)[C@H](O[C@@]6([H])C[C@H](OC)[C@@H](O[C@]7([H])O[C@@H](C)[C@H](O)[C@@H](OC)C7)[C@H](C)O6)/C(C)=C/C3)(O)[C@@]5([H])[C@H](O)C(C)=C4)=O)C2)O1.C[C@H]8C=C[C@@]9(O[C@@]%10([H])C[C@]([H])(OC([C@@]%11([H])[C@@](/C(CO%12)=C/C=C/[C@H](C)[C@H](O[C@@]%13([H])C[C@H](OC)[C@@H](O[C@]%14([H])O[C@@H](C)[C@H](O)[C@@H](OC)C%14)[C@H](C)O%13)/C(C)=C/C%10)(O)[C@@]%12([H])[C@H](O)C(C)=C%11)=O)C9)O[C@@H]8C(C)C
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| 基本信息： |
CAS：71751-41-2
中文名称：阿维菌素
英文名称：Avermectin
别名：Avermectin B1a-Avermectin B1b mixt.Avermectin B1;阿维菌素 B1
分子式：B1a:C48H72O14;B1b:C47H70O14
分子量：B1a:873.09;B1b:859.06
规格：200mg ; 100mg
溶解性：Soluble in DMSO ≥25mg/mL
纯度：≥98%
外观(性状)：White to yellow Solid
储存条件：Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
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| 靶点： |
Parasite |
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