背景说明：Neuropeptide Y (13-36)， amide， human 是选择性的神经肽 Y2 受体 (neuropeptide Y2 receptor) 的激动剂。 In Vivo：Neuropeptide Y (13-36) (intraventricular injection; 25-3000 pmol) produces a dose-dependent increase (up to 14%; ED50 value of 0.3 nmol for overall effects and 0.97 nmol for the peak effects) in mean arterial blood pressure in the awake， unrestrained male rat without affecting heart rate. Central administration of porcine Neuropeptide Y (13-36) produces marked vasodepressor and bradycardic actions in the anaesthetized α-chloralose and in the awake unrestrained male rat. Neuropeptide Y (13-36) (intracerebroventricular injection; 50 ng; alone; injected 30 and 15 min before measurements) injected into na ve mice impairs social novelty preference， but not sociability， and this effect is inhibited by the NPY Y2 receptor antagonist BIIE 0246. 参考文献：[1]. Aguirre JA， et al. Centrally injected neuropeptide Y (13-36) produces vasopressor effects and antagonizes the vasodepressor action of neuropeptide Y (1-36) in the awake male rat. Neurosci Lett. 1990 Oct 2;118(1):5-8. [2]. Daiki Ueda， et al. Increase in neuropeptide Y activity impairs social behaviour in association with glutamatergic dysregulation in diabetic mice. Br J Pharmacol. 2021 Feb;178(3):726-740.
基本信息：
产品类型：多肽 CAS：122341-40-6 单字母序列：PAEDMARYYSALRHYINLITRQRY-NH2 三字母序列：Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2 别名：Neuropeptide Y (13-36)，human 分子式：C134H207N41O36S1 分子量：3000.4 纯度：≥95% 外观(性状)：冻干粉;Lyophilized powder 盐体系：TFA盐;Trifluoroacetate salt 来源：合成;Synthetic 储存条件：Store at -20℃，2 years.(Avoid freeze/thaw cycles) 类别/标签：神经肽及相关肽(Neuropeptides and Related Peptides) 规格：5mg ; 1mg
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