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背景说明：Neuromedin N 是大鼠多巴胺 D2 受体激动剂结合新纹状体膜的有效调节剂。Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.
In Vitro：Neuromedin N competitively inhibits the binding of neurotensin to rat brain synaptic membranes with a 19-fold lower potency than neurotensin and is rapidly inactivated by brain synaptic peptidases.
It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin.
参考文献：[1] De Nadai F. et al. Brain Res. 500, 193 (1989);
[2] Minamino, N. et al. Biochem. Biophys. Res. Commun. 122, 542 (1984).
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