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背景说明：This is an N-terminally biotinylated peptide. The sequence APRTPGGRR contains a native sequence derived from bovine myelin basic protein amino acids 95-98 (PRTP). The rest of the sequence is not derived from a native sequence, but is a synthetic construct. This substrate is specific for MAP kinases: p44MAPK [extracellular signal-regulated kinase 1 (ERK1)] and p42MAPK (ERK2). It contains the consensus sequence Pro-X-(Ser/Thr)-Pro that is recognized by MAP kinase. This peptide is the most efficient substrate for phosphorylation reaction by ERK. The substrate is phosphorylated by kinases on threonine 97 and can also be phosphorylated by MAPK p38. 这是一种N端生物素化肽。序列aprtpgrr包含一个来自牛髓鞘碱性蛋白氨基酸95-98（PRTP）的天然序列。序列的其余部分不是从本地序列派生的，而是一个合成结构。这种底物对MAP激酶有特异性：p44MAPK[细胞外信号调节激酶1（ERK1）]和p42MAPK（ERK2）。它包含由MAP激酶识别的共有序列Pro-X-（Ser/Thr）-Pro。该肽是ERK磷酸化反应最有效的底物。底物被苏氨酸97上的激酶磷酸化，也可以被MAPK p38磷酸化。
In Vitro：未检测
参考文献：[1] Sommer, F. et al. Int. J. Impot. Res. 14, 217 (2002);
[2] Lents, NH. et al. Ann. N. Y. Acad. Sci. 973, 265 (2002);
[3] Kameshita, I. et al. J. Biochem. (Tokyo) 122, 168 (1997).
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