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背景说明：Gap19 是一种衍生自 Cx43 细胞质环 (CL) 九个氨基酸的肽，一种有效的，选择性连接蛋白 43 (Cx43) 半通道阻滞剂。Gap19 可以防止 C 末端 (CT) 与 CL 的分子内相互作用。Gap19 不阻断 GJ 通道或 Cx40/pannexin-1 半通道。Gap19 对心肌具有保护作用。
In Vivo：Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth.
In Vitro：Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake.
Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells.
Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes.
Gap19 (250 μM， 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo.
参考文献：[1]. Boengler K， et al. Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 2013 Jun 6;4:73.
[2]. Wang N， et al. Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res Cardiol. 2013 Jan;108(1):309.
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