| 抗体信息： |
靶标：HIV1 gp120
别名：HIV-1 ENV (gp120);HIV1 gp120;HIV1gp120;HIV-1 gp120;Envelope surface glycoprotein gp120;Glycoprotein 120;gp120;gp120 glycoprotein;Human Immunodeficiency Virus 1;SU;Surface protein
背景说明：The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CXCR4 and/or CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. Since CD4 also displays a binding site for the disulfide-isomerase P4HB/PDI, a P4HB/PDI-CD4-CXCR4-gp120 complex may form. In that complex, P4HB/PDI could reach and reduce gp120 disulfide bonds, causing major conformational changes in gp120. TXN, another PDI family member could also be involved in disulfide rearrangements in Env during fusion. These changes are transmitted to the transmembrane protein gp41 and are thought to activate its fusogenic potential by unmasking its fusion peptide.
Swiss Prot：P05877
亚细胞定位：Cell membrane
免疫原：A synthetic peptide of human HIV1 gp120
Public Immunogen Range：301-334/857aa
理论分子量：53/91kDa
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