| 生物活性： |
靶点：Adrenergic Receptor
通路：Endocrinology & Hormones;GPCR & G Protein；Neuronal Signaling
背景说明：是一种长效的 β2-AR 激动剂。
生物活性：Vilanterol Trifenate 是一种长效β2-肾上腺素受体（β2-AR）激动剂，具有 24 小时固有活性，对 β2-AR、β1-AR 和 β3-AR 的 pEC50 分别为 10.37、6.98 和 7.36。[1-2]
In Vitro：Vilanterol trifenatate(vilanterol)displayed a subnanomolar affinity for the β(2)-AR，vilanterol demonstrated similar selectivity as salmeterol for β(2)- over β(1)-AR and β(3)-AR.[1]
In Vivo：In human airways，vilanterol was shown to have a faster onset and longer duration of action than salmeterol，exhibiting a significant level of bronchodilation 22 h after treatment.[1] Vilanterol(VI; 25-100 μg; once daily，14 days)was well tolerated asthma and COPD，and produced a rapid and prolonged bronchodilation over 24 h.[2]
数据来源文献：[1]. Slack RJ，et al. In vitro pharmacological characterization of vilanterol，a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action. J Pharmacol Exp Ther. 2013 Jan;344(1):218-30.
[2]. Kempsford R，et al. Vilanterol trifenatate，a novel inhaled long-acting beta2 adrenoceptor agonist，is well tolerated in healthy subjects and demonstrates prolonged bronchodilation in subjects with asthma and COPD. Pulm Pharmacol Ther. 2013 Apr;26(2):256-64.
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| 其它标识： |
SMILES：C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)O.C1=CC(=C(C(=C1)Cl)COCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O)Cl
InChIKey：KLOLZALDXGTNQE-JIDHJSLPSA-N
InChI：InChI=1S/C24H33Cl2NO5.C20H16O2/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28;21-19(22)20(16-10-4-1-5-11-16，17-12-6-2-7-13-17)18-14-8-3-9-15-18/h5-9，14，24，27-30H，1-4，10-13，15-17H2;1-15H，(H，21，22)/t24-;/m0./s1
PubChem CID：44482554
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| 基本信息： |
CAS：503070-58-4
中文名称：维兰特罗三苯乙酸盐
英文名称：Vilanterol Trifenate
别名：GW642444M Trifenate
分子式：C44H49Cl2NO7
分子量：774.77
规格：1mg
溶解性：Soluble in DMSO ≥10mg/mL
纯度：≥98%
外观(性状)：White to off-white Solid
储存条件：Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
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| 靶点： |
Adrenergic Receptor |
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