| 生物活性： |
靶点：Reactive oxygen species (ROS)
通路：Immunology & Inflammation
背景说明：是一种双黄酮类化合物,具有很多生物活性,包括抗炎、抗氧化、神经保护等作用。
生物活性：Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.[1-2]
In Vitro：Amentoflavone induces morphological changes and reduces the percentage of viable MCF-7 cells. Amentoflavone induces apoptosis and chromatin condensation，DNA strand breaks in MCF-7 cells. Amentoflavone is also reported to induce cell-cycle arrest at the sub-G1 phase，and apoptosis via mitochondria-emanated intrinsic pathways in SiHa and CaSki human cervical cancer cells[1].
In Vivo：In an animal model，amentoflavone is found to significantly inhibit B16F-10 melanoma-induced solid tumor development in C57BL/6 mice[1]. Amentoflavone can cross the blood-brain barrier. It effectively prevents pilocarpine-induced epilepsy in a mouse kindling model，suppresses NF-kB activation and expression，inhibits excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures，shortened attack time，and diminished loss and apoptosis of hippocampal neurons[2].
细胞实验：Approximately 2×105 MCF-7 cells/well in 24-well plates are treated with 250 μM amentoflavone，or with vehicle(DMSO，0.1% in culture media)-only and all cells are incubated for 6 to 72 h. For the examination of morphological changes，cells are photographed under a phase-contrast microscope.[1]
动物实验：Animal Models: Kunming mice;Dosages: 25 mg/kg;Administration: intragastrically administered[2]
数据来源文献：[1] Pei JS， et al. In Vivo. 2012， 26(6):963-70.
[2] Zhang Z， et al. Neural Regen Res. 2015， 10(7):1125-33.
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| 其它标识： |
MDL：MFCD00017470
SMILES：O=C1C=C(C2=CC=C(O)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4O)C(O)=CC(O)=C13
InChIKey：YUSWMAULDXZHPY-UHFFFAOYSA-N
InChI：InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H
PubChem CID：5281600
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| 基本信息： |
CAS：1617-53-4
中文名称：穗花杉双黄酮
英文名称：Amentoflavone
别名：穗花杉双黄酮;阿曼托黄酮;Amentoflavone;Didemethyl-ginkgetin;
分子式：C30H18O10
分子量：538.46
规格：10mM*1mL in DMSO ; 5mg ; 10mg
溶解性：Soluble in DMSO ≥10mg/mL
纯度：HPLC≥98%
外观(性状)：Light yellow to yellow-green Solid
储存条件：Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
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| 靶点： |
Reactive oxygen species (ROS) |
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