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背景说明：The synthetic peptide Gly-Arg-Gly-Asp-Ser (GRGDS) mimics the cellular binding site of many adhesive proteins in the extracellular matrix and causes rounding and detachment of spread cells. The GRGDS (Gly-Arg-Gly-Asp-Ser) peptide has intermediate affinity to V3 and IIb3, which are the integrins most reported to be involved in bone function.
In Vitro：Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3, with IC50 of 5 μM.
Gly-Arg-Gly-Asp-Ser-immobilized TiO2 nanotubes enhance osteoblast-like cell (MG-63) adhesion, and significantly increased cell spreading and proliferation.
参考文献：[1] Senger DR and Perruzzi CA. Biochim Biophys Acta. 1314, 13-24 (1996);
[2] Stickel, SK. and YL. Wang. J. Cell Biol. 107, 1231 (1988).
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