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背景说明：GRGDSP 是一种合成的线性RGD肽，是一种整联蛋白 (integrin) 抑制剂。GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor.
In Vitro：It is demonstrated that transarterial infusion of GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro integrin-inhibitor which includes RGD-peptide). As a synthetic linear RGD peptide, GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis.
GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) is used as a soluble integrin-blocking RGD-based peptide. GRGDSP is used widely together with other RGD peptides in integrin research. GRGDSP can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization.
参考文献：[1] Kang, I-C. et al. Cancer Res. 59, 3754 (1999).
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