| 抗体信息： |
靶标：PCNA
别名：Proliferation Marker, Cyclin, DNA polymerase delta auxiliary protein, HGCN8729, MGC8367, Mutagen-sensitive 209 protein, Pcna/cyclin, PCNAR, Polymerase delta accessory protein, Proliferating Cell Nuclear Antigen, PCNA_HUMAN
背景说明：Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
Swiss Prot：P12004
Gene ID：5111
亚细胞定位：Nucleus
免疫原：A synthetic peptide of human PCNA
Public Immunogen Range：150-200/261aa
理论分子量：29kDa
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