| 生物活性： |
背景说明：Adrenocorticotropic Hormone (ACTH) (18-39), human 是一种似皮质促素中叶肽，产生于垂体中叶的促黑素细胞。Adrenocorticotropic Hormone (ACTH) (18-39), human is a corticotropinlike intermediate lobe peptide, which is produced in the melanotrophs of the intermediate lobe of the pituitary.
In Vitro：The ACTH family of polypeptides consists of ACTH(1-39) (adrenocorticotropin), ACTH (1-13)amide (α-melanotropin;α-MSH); and ACTH (18-39) (corticotropinlike intermediate lobe peptide, CLIP). These polypeptides are derived from a common precursor, proopiomelanocortin. In corticotropic cells of the pars distalis, proopiomelanocortin (POMC) undergoes a series of proteolytic cleavage reactions to yield ACTH (1-39) as a major end product. However, in the melanotropic cells of the pars intermedia, an additional set of proteolytic reactions results in the conversion of ACTH (1-39) to ACTH (1-13) amide and ACTH (18-39). In several species of vertebrates, ACTH (1-13) amide undergoes end product modification to yield mono- and diacetylated forms ofα-MSH as major end products in the pars intermedia.
参考文献：[1] Scott, AP. et al. J. Endocrinol. 61, 355 (1974);
[2] Bellingham, NA. et al. J. Endocrinol 94, 125 (1982);
[3] Marshall, JB. et al. J. Clin. Invest. 74, 1886 (1984);
[4] Zaphiropoulos, A. et al. Brain Res. Bull. 26, 99 (1991).
|
扫一扫关注我们
