| 生物活性： |
背景说明：Protease-Activated Receptor-4 是转化生长因子受体 4 的激动剂。Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4).
In Vitro：GYPGKF-NH2 significantly reduces the agonistic potency of AYPGKF-NH2 by 25-fold.
GYPGKF-NH2 (500 μM) does not cause contraction or relaxation of the guinea pig IAS strips.
参考文献：[1] Fang, J. et al. Blood 106, 2671(2005);
[2] Mulè, F. et al. Gut. 53, 229 (2004);
[3] Sekiguchi, F. et al. Drug Design Rev. 1, 287 (2004);
[4] Faruqi, T. et al. J. Biol. Chem. 275, 19728 (2000);
[5] Greenberg, D. Biochem. 42, 2702 (2003);
[6] Henriksen, R. and V. Hanks, Arterioscler. Thromb. Vasc. Biol. 22, 861 (2002);
[7] Gui, Y. et al. Am. J. Physiol. Renal. Physiol. 285, 95 (2003).
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