| 生物活性： |
背景说明：TRAP-6 (PAR-1 agonist peptide)，一种多肽片段，是选择性的蛋白酶激活受体 1 (PAR1) 激动剂。TRAP-6 通过凝血酶受体激活人血小板。TRAP-6 对 PAR4 无活性。TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4.
In Vivo：TRAP (1 mg/kg; i.v.) produces a biphasic response in blood pressure in inactin-anesthetized rats.
In Vitro：TRAP-6 (0.01-10 μM) triggers calcium mobilization in Xenopus oocytes heterologously expressing PAR1.
TRAP-6 (0.01-10 μM; 30 min) activates human platelets.
TRAP-6 (100 μM) does not cause the platelets of rabbits or rats to change shape, aggregate, release granule contents, or form thromboxane.
参考文献：[1] Scarborough, RM. et al. J. Biol. Chem. 267, 13146 (1992);
[2] Ahmad, S. and PN. Walsh, Biochem. 44, 13858 (2005);
[3] Buergler, M. et al. J. Thromb. Thrombolysis 19, 115 (2005).
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