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背景说明:D-JBD19 是一种不可渗透性的多肽。D-JBD19 具有神经保护作用。D-JBD19 is a non-permeable peptide. D-JBD19 has neuroprotective effects[2]. In Vivo:Neuroprotective effects of D-JBD19 against middle cerebral artery occlusion (MCAO) as compared with D-JNKI1. 15.7 ng of either D-JBD19 or D-JNKI1 or 1570 ng of D-JBD19 are injected i.c.v. just after the ischemia. Animals were killed 24 h later. 100 times more D-JBD19 is needed to provide protection than with D-JNKI1. In Vitro:D-JBD19 is a non-permeable cargo corresponding to dJNKi peptide. 参考文献:[1] Cardozo AK, et al. Cell-permeable peptides induce dose-and length-dependent cytotoxic effects. Biochim Biophys Acta. 2007 Sep;1768(9):2222-34.
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