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背景说明：Antileukinate 是一种六肽，是有效的 CXC 趋化因子受体 (CXCR) 抑制剂。Antileukinate 能抑制中性粒细胞趋化和活化。Antileukinate 可用于急性炎症和损伤的研究。Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury.
In Vivo：Antileukinate (52.63 mg/kg; s.c.) protectes mice against acute pancreatitis and associated lung injury.
Antileukinate (5mg/kg; s.c.) inhibits the interaction between murine eotaxin and murine eosinophil.
In Vitro：Antileukinate inhibits the binding of human eotaxin to human eosinophils with an IC50 of 8.2 μM.
Antileukinate (10-100 μM; 2 hours) significantly suppresses eosinophil chemotaxis to human eotaxin.
参考文献：[1] Hayashi, S. et al. J. Immunol. 154, 814 (1995).
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