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背景说明:Substance P(1-4) 是一种有效的神经激肽受体(NK-R)拮抗剂;Substance P(1-4) 对正常造血有调节作用,抑制内源性红细胞集落 (EEC) 的形成。 Substance P(1-4) is a potent neurokinin receptors (NK-R) antagonist. Substance P(1-4) has regulation of normal hematopoiesis and inhibits endogenous erythroid colony (EEC) formation. In Vitro:Substance P(1-4) (0.1 nM-1 μM) inhibits endogenous erythroid colony (EEC) formation in PV bone marrow cultures. Substance P(1-4) (0.1 nM-1 μM; CD36+/GpA- cells) decreases of erythroid colony numbers of 47% and inhibits proliferation of PV CD36+/GpA- cells of 30 %.
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