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背景说明：A competitive antagonist at receptors for substance P, for bombesin and for cholecystokinin.
In Vitro：When a fraction from rabbit brain enriched in glial cells was incubated with [3H]Substance P (5-11), an uptake of [3H]Substance P (5-11) is observed. When Substance P is released from nerve terminals, it is hydrolysed into Substance P (5-11), which is in turn accumulated into glial cells as well as nerve terminals and that this high affinity uptake mechanism may play an important role in terminating the synaptic action of Substance P.
参考文献：[1] L.Zhang et al., Biochim. Biophys. Acta, 972, 37(1988).
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