| Elisa信息： |
Swiss Prot：P23359
Gene ID：12162
背景说明：Bone morphogenetic protein 7 (BMP7, also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene[1] and belong to BMP family and the TGF-β superfamily. Like other members of the BMP family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage. It is inhibited by noggin and a similar protein, chordin, which are expressed in the Spemann-Mangold Organizer. BMP7 may be involved in bone homeostasis. It is expressed in the brain, kidneys and bladder. [2] BMP7 induces the phosphorylation of SMAD1 and SMAD5, which in turn induce transcription of numerous osteogenic genes.[3] It has been demonstrated that BMP7 treatment is sufficient to induce all of the genetic markers of osteoblast differentiation in many cell types.[2] Human recombinant BMP7 has surgical uses and is marketed under the brand name OP1. It can be used to aid in the fusion of vertebral bodies to prevent neurologic trauma.[4] Also in the treatment of tibial non-union, frequently in cases where a bone graft has failed.[5] BMP7 also has the potential for treatment of chronic kidney disease.[6][7] BMP7 administration has been proposed as a possible treatment for human infertility.[8] It was discovered that mice injected with BMP7 increased their production of good brown fat cells. [9]
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