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背景说明:Human Siglec-15 is a transmembrane glycoprotein in the Siglec family.Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO--terminus is cytosolic.Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid.These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold.All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity.Siglecs differ in the number of these C2-type domains.Human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD) with two Ig-like domains,a 21 aa transmembrane segment,and a 44 aa cytoplasmic domain.Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts 来源:Human Cells
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溶剂:Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 内毒素:Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.
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别名:Angiopoietin-related protein 4;425O18-1;Angiopoietin-like protein 4;Fasting-induced adipose factor;Hepatic fibrinogen/angiopoietin-related protein;HFARP;Secreted protein Bk89;Angptl4;Farp;Fiaf;Ng27 中文名称:Recombinant Human Siglec-15/CD33L3/Sialic acid-binding Ig-like lectin 15 规格:10ug ; 50ug ; 500ug ; 1mg 外观(性状):Lyophilized from a 0.2 μm filtered solution of PBS, 150mM NaCl, 0.3% Chaps, 5% Trehalose, pH 7.4. 纯度:≥95% as determined by reducing SDS-PAGE. 储存条件:Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
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