| 生物活性： |
靶点：Cav3.2 channels
通路：Membrane Transporter&Ion Channel;Neuronal Signaling
背景说明：Sodium Ascorbate是一种电子供体和内源性抗氧化剂，还是一种胶原沉积促进剂和弹性生成抑制剂。Sodium Ascorbate可以选择性抑制 Cav3.2 通道(Cav3.2 channels)。
生物活性：L-Ascorbic acid sodium salt (Sodium L-ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor[1-3].
In Vitro：The conditioned medium for B16F10 cells significantly inhibits cell apoptosis induced by L-Ascorbic acid sodium salt(Sodium L-ascorbate)(10 mM)，and the effective ingredients in the medium show a relative molecular mass below 5，000[4].
In Vivo：Tg rats treated with L-Ascorbic acid sodium salt(Sodium L-ascorbate)show a higher incidence of carcinoma(29.6%)，compared to those without L-Ascorbic acid sodium salt(15.4%). Independent of the L-Ascorbic acid sodium salt treatment，transgenic rats exhibit various kinds of malignant tumors in various organs[5].
动物实验：A total of 40 7-week-old male Tg rats are divided into 2 groups. Twenty-seven(group 1)and 13(group 2)rats are given a powdered MF diet with or without 5% sodium L-ascorbate，respectively. Similarly，a total of 42 7-week-old male Non-tg rats are divided into 2 groups，and 30(group 3)and 12(group 4)animals are given a diet with or without 5% sodium L-ascorbate，respectively.[3]
数据来源文献：[1]. Hinek A， et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.
[2]. Aleksander Hinek， et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.
[3]. Michael T Nelson， et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83.
[4]. Yang X， et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50.
[5]. Morimura K， et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7.
[6]. Takagi H， et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53.
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| 其它标识： |
EC：EINECS 205-126-1
MDL：MFCD00082340
SMILES：C(C(C1C(=C(C(=O)O1)O)[O-])O)O.[Na+]
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| 基本信息： |
CAS：134-03-2
中文名称：抗坏血酸钠
英文名称：Sodium Ascorbate
别名：(+)-Sodium L-ascorbate;Sodium L-ascorbate;L-Ascorbic acid sodium;Vitamin C sodium salt;维生素C钠;L-Ascorbic acid sodium salt
分子式：C6H7NaO6
分子量：198.11
规格：100mg ; 10mM*1mL in Water ; 200mg ; 500mg
溶解性：Soluble in Water ≥10mg/mL
纯度：≥98%
外观(性状)：Off-white to light yellow Solid
储存条件：Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
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| 靶点： |
Cav3.2 channels |
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