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背景说明：CEF3 (SIIPSGPLK) 对应于甲型流感病毒M1蛋白的13-21氨基酸序列。甲型流感病毒M1蛋白是一种多功能蛋白质，在病毒生命周期中起着重要的结构和功能作用。CEF3 (SIIPSGPLK) corresponds to aa 13-21 of the influenza A virus M1 protein. The matrix (M1) protein of influenza A virus is a multifunctional protein that plays essential structural and functional roles in the virus life cycle.
In Vitro：The matrix (M1) protein of influenza A virus is a multifunctional protein that plays essential structural and functional roles in the virus life cycle. It drives virus budding and is the major protein component of the virion, where it forms an intermediate layer between the viral envelope and integral membrane proteins and the genomic ribonucleoproteins (RNPs). It also helps to control the intracellular trafficking of RNPs. These roles are mediated primarily via protein-protein interactions with viral and possibly cellular proteins.
The influenza virus M1 is required to induce vRNP nuclear export but that cellular phosphorylation is an additional factor. The influenza virus M1 protein is fundamental to a late event in the virus life cycle-the transfer of vRNPs from the nucleus to the cytosol.
参考文献：[1] Gianfrani C. et al. Human Immunol. 61, 438 (2000);
[2] Macken, C. et al. "The value of a database in surveillance and vaccine selection." in Options for the Control of Influenza IV. A.D.M.E. Osterhaus, N. Cox & A.W. Hampson (Eds.) Amsterdam: Elsevier Sci; Berkhoff, E. et al. J. Virol. 78: 5216 (2004).
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